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Directed Evolution of Aerotolerance in Sulfide-Dependent Thiazole Synthases

[Image: see text] Sulfide-dependent THI4 thiazole synthases could potentially be used to replace plant cysteine-dependent suicide THI4s, whose high protein turnover rates make thiamin synthesis exceptionally energy-expensive. However, sulfide-dependent THI4s are anaerobic or microoxic enzymes and he...

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Detalles Bibliográficos
Autores principales:	Gelder, Kristen Van, Oliveira-Filho, Edmar R., García-García, Jorge Donato, Hu, You, Bruner, Steven D., Hanson, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127261/ https://www.ncbi.nlm.nih.gov/pubmed/36920242 http://dx.doi.org/10.1021/acssynbio.2c00512

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