Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

BACKGROUND: Carbonic anhydrases catalyze CO(2)/HCO(3)(–) buffer reactions with implications for effective H(+) mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal cell functions, their interactions, and patient prognos...

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Detalles Bibliográficos
Autores principales: Lee, Soojung, Toft, Nicolai J., Axelsen, Trine V., Espejo, Maria Sofia, Pedersen, Tina M., Mele, Marco, Pedersen, Helene L., Balling, Eva, Johansen, Tonje, Burton, Mark, Thomassen, Mads, Vahl, Pernille, Christiansen, Peer, Boedtkjer, Ebbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127511/
https://www.ncbi.nlm.nih.gov/pubmed/37098526
http://dx.doi.org/10.1186/s13058-023-01644-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127511/
https://www.ncbi.nlm.nih.gov/pubmed/37098526
http://dx.doi.org/10.1186/s13058-023-01644-1

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