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Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer
BACKGROUND: Carbonic anhydrases catalyze CO(2)/HCO(3)(–) buffer reactions with implications for effective H(+) mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal cell functions, their interactions, and patient prognos...
Autores principales: | Lee, Soojung, Toft, Nicolai J., Axelsen, Trine V., Espejo, Maria Sofia, Pedersen, Tina M., Mele, Marco, Pedersen, Helene L., Balling, Eva, Johansen, Tonje, Burton, Mark, Thomassen, Mads, Vahl, Pernille, Christiansen, Peer, Boedtkjer, Ebbe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127511/ https://www.ncbi.nlm.nih.gov/pubmed/37098526 http://dx.doi.org/10.1186/s13058-023-01644-1 |
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