Biocatalytic Synthesis of Homochiral 2-Hydroxy-4-butyrolactone Derivatives by Tandem Aldol Addition and Carbonyl Reduction

[Image: see text] Chiral 2-hydroxy acids and 2-hydroxy-4-butyrolactone derivatives are structural motifs often found in fine and commodity chemicals. Here, we report a tandem biocatalytic stereodivergent route for the preparation of these compounds using three stereoselective aldolases and two stere...

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Detalles Bibliográficos
Autores principales: Moreno, Carlos J., Hernández, Karel, Gittings, Samantha, Bolte, Michael, Joglar, Jesús, Bujons, Jordi, Parella, Teodor, Clapés, Pere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127515/
https://www.ncbi.nlm.nih.gov/pubmed/37123603
http://dx.doi.org/10.1021/acscatal.3c00367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127515/
https://www.ncbi.nlm.nih.gov/pubmed/37123603
http://dx.doi.org/10.1021/acscatal.3c00367

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