Dysregulating PHO Signaling via the CDK Machinery Differentially Impacts Energy Metabolism, Calcineurin Signaling, and Virulence in Cryptococcus neoformans

Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 kinase-Pho80 cyclin-CDK inhibitor Pho81), providing drug-targeting opportunities. Here, we investigate the impact of a PHO pathway acti...

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Detalles Bibliográficos
Autores principales: Bowring, Bethany Grace, Sethiya, Pooja, Desmarini, Desmarini, Lev, Sophie, Tran Le, Lisa, Bahn, Yong-Sun, Lee, Seung-Heon, Toh-e, Akio, Proschogo, Nicholas, Savage, Tom, Djordjevic, Julianne Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127591/
https://www.ncbi.nlm.nih.gov/pubmed/37017534
http://dx.doi.org/10.1128/mbio.03551-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127591/
https://www.ncbi.nlm.nih.gov/pubmed/37017534
http://dx.doi.org/10.1128/mbio.03551-22

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