SERINC5 Mediates a Postintegration Block to HIV-1 Gene Expression in Macrophages

HIV-1 antagonizes SERINC5 by redundant mechanisms, primarily through Nef and additionally via envelope glycoprotein. Paradoxically, HIV-1 preserves Nef function to ensure the exclusion of SERINC5 from virion incorporation regardless of the availability of envelope that can confer resistance, suggest...

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Detalles Bibliográficos
Autores principales: Ramdas, Pavitra, Chande, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127607/
https://www.ncbi.nlm.nih.gov/pubmed/36976020
http://dx.doi.org/10.1128/mbio.00166-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127607/
https://www.ncbi.nlm.nih.gov/pubmed/36976020
http://dx.doi.org/10.1128/mbio.00166-23

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