The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway

JC polyomavirus (JCPyV) is a ubiquitous, double-stranded DNA virus that causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. Current treatments for PML are limited to immune reconstitution, and no effective antivirals exist. In this r...

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Detalles Bibliográficos
Autores principales: Kaiserman, Jacob, O’Hara, Bethany A., Garabian, Kaitlin, Lukacher, Avraham, Haley, Sheila A., Atwood, Walter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127638/
https://www.ncbi.nlm.nih.gov/pubmed/36786589
http://dx.doi.org/10.1128/mbio.03583-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127638/
https://www.ncbi.nlm.nih.gov/pubmed/36786589
http://dx.doi.org/10.1128/mbio.03583-22

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