MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection

Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells. All three pathways share common upstream regulators, namely, ZBP1 and RIPK3. Yet, the molecular mechanis...

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Detalles Bibliográficos
Autores principales: Lei, Xuqiu, Chen, Yongzhi, Lien, Egil, Fitzgerald, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127685/
https://www.ncbi.nlm.nih.gov/pubmed/36852999
http://dx.doi.org/10.1128/mbio.00110-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127685/
https://www.ncbi.nlm.nih.gov/pubmed/36852999
http://dx.doi.org/10.1128/mbio.00110-23

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