SARS-CoV-2 SUD2 and Nsp5 Conspire to Boost Apoptosis of Respiratory Epithelial Cells via an Augmented Interaction with the G-Quadruplex of BclII

The molecular mechanisms underlying how SUD2 recruits other proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to exert its G-quadruplex (G4)-dependent pathogenic function is unknown. Herein, Nsp5 was singled out as a binding partner of the SUD2-N+M domains (SUD2(core)) with hi...

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Detalles Bibliográficos
Autores principales: Li, Ying, Yu, Quanwei, Huang, Ridong, Chen, Hai, Ren, Hequan, Ma, Lingling, He, Yang, Li, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127692/
https://www.ncbi.nlm.nih.gov/pubmed/36853058
http://dx.doi.org/10.1128/mbio.03359-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127692/
https://www.ncbi.nlm.nih.gov/pubmed/36853058
http://dx.doi.org/10.1128/mbio.03359-22

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