Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease

Auxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of-function mutations cause early-onset Parkinson’s disease (PD). Here, we utilized auxilin knockout (KO) mice to eluci...

Descripción completa

Detalles Bibliográficos
Autores principales: Vidyadhara, D.J., Somayaji, Mahalakshmi, Wade, Nigel, Yücel, Betül, Zhao, Helen, Shashaank, N., Ribaudo, Joseph, Gupta, Jyoti, Lam, TuKiet T., Sames, Dalibor, Greene, Lois E., Sulzer, David L., Chandra, Sreeganga S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127800/
https://www.ncbi.nlm.nih.gov/pubmed/36920906
http://dx.doi.org/10.1016/j.celrep.2023.112231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127800/
https://www.ncbi.nlm.nih.gov/pubmed/36920906
http://dx.doi.org/10.1016/j.celrep.2023.112231

Ejemplares similares