Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication

Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins. Using a loss-of-function CRISPR screen, we show that synthesis of a flavivirus-encoded fluorescent reporter...

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Detalles Bibliográficos
Autores principales: Ohlson, Maikke B., Eitson, Jennifer L., Wells, Alexandra I., Kumar, Ashwani, Jang, Seoyeon, Ni, Chunyang, Xing, Chao, Buszczak, Michael, Schoggins, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128003/
https://www.ncbi.nlm.nih.gov/pubmed/36809113
http://dx.doi.org/10.1128/mbio.00127-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128003/
https://www.ncbi.nlm.nih.gov/pubmed/36809113
http://dx.doi.org/10.1128/mbio.00127-23

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