Cargando…

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells

Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved in the evasion of the murine IFNγ response have been identified, genes required to survive the human IFNγ response are largely unkno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krishnamurthy, Shruthi, Maru, Parag, Wang, Yifan, Bitew, Mebratu A., Mukhopadhyay, Debanjan, Yamaryo-Botté, Yoshiki, Paredes-Santos, Tatiana C., Sangaré, Lamba O., Swale, Christopher, Botté, Cyrille Y., Saeij, Jeroen P. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128063/ https://www.ncbi.nlm.nih.gov/pubmed/36916910 http://dx.doi.org/10.1128/mbio.00060-23

Ejemplares similares

Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma
por: Paredes-Santos, Tatiana C., et al.
Publicado: (2023)

CRISPR screen to determine the in vivo fitness of Toxoplasma genes
por: Sangaré, Lamba Omar, et al.
Publicado: (2021)

Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability
por: Renaud, Eléa A., et al.
Publicado: (2022)

Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage
por: Dass, Sheena, et al.
Publicado: (2021)

Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii
por: Bansal, Priyanka, et al.
Publicado: (2021)

Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages
por: Wang, Yifan, et al.
Publicado: (2020)

Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors
por: Sangaré, Lamba Omar, et al.
Publicado: (2019)

Variation in Lipid Species Profiles among Leukemic Cells Significantly Impacts Their Sensitivity to the Drug Targeting of Lipid Metabolism and the Prognosis of AML Patients
por: Lo Presti, Caroline, et al.
Publicado: (2023)

An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum
por: Asad, Mohd, et al.
Publicado: (2021)

Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts
por: Krishnamurthy, Shruthi, et al.
Publicado: (2018)

Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection
por: Mukhopadhyay, Debanjan, et al.
Publicado: (2020)

Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11
por: Mukhopadhyay, Debanjan, et al.
Publicado: (2020)

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase
por: Amiar, Souad, et al.
Publicado: (2016)

Toxoplasma metabolic flexibility in different growth conditions
por: Walsh, Daniel, et al.
Publicado: (2022)

Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria
por: Bouabid, Cyrine, et al.
Publicado: (2022)

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites
por: Botté, Cyrille Y., et al.
Publicado: (2011)

The human immune response to Toxoplasma: Autophagy versus cell death
por: Krishnamurthy, Shruthi, et al.
Publicado: (2017)

Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis
por: Wang, Yifan, et al.
Publicado: (2019)

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
por: Vanwalleghem, Gilles, et al.
Publicado: (2015)

Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector
por: Tomita, Tadakimi, et al.
Publicado: (2021)

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity
por: Lecordier, Laurence, et al.
Publicado: (2020)

New Avenues to Design Toxoplasma Vaccines Based on Oocysts and Cysts
por: Arranz-Solís, David, et al.
Publicado: (2022)

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress
por: Nofal, Stephanie D., et al.
Publicado: (2022)

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death
por: Saeij, Jeroen P, et al.
Publicado: (2017)

Los americanos en México
por: Botte, M. Louis
Publicado: (1967)

El precio de un niño : cuatro años en el infierno de la prostitución infantil en Bangkok
por: Botte, Marie-France
Publicado: (1995)

Augmenting Quality and Throughput of Functional Testing and Device Characterization for the ABCStar ATLAS-ITk Strips Readout ASIC Through a Semiconductor Test Industry Partnership
por: Botte, James Michael
Publicado: (2021)

Identification of a Master Regulator of Differentiation in Toxoplasma
por: Waldman, Benjamin S., et al.
Publicado: (2020)

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response
por: Niedelman, Wendy, et al.
Publicado: (2012)

Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet
por: Iuso, Domenico, et al.
Publicado: (2023)

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5
por: Kongsomboonvech, Angel K., et al.
Publicado: (2020)

Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species
por: Hassan, Musa A., et al.
Publicado: (2019)

The flexibility of Apicomplexa parasites in lipid metabolism
por: Shunmugam, Serena, et al.
Publicado: (2022)

Perovskite solar cell for photocatalytic water splitting with a TiO(2)/Co-doped hematite electron transport bilayer
por: Roy, Subhasis, et al.
Publicado: (2018)

Electrochemical valorization of waste activated sludge for short-chain fatty acids production
por: Jafari, Maasoomeh, et al.
Publicado: (2022)

Reduced Graphene Oxide-Coated Fabrics for Joule-Heating and Antibacterial Applications
por: Jafari, Behnaz, et al.
Publicado: (2023)

Toxoplasma gondii Clonal Strains All Inhibit STAT1 Transcriptional Activity but Polymorphic Effectors Differentially Modulate IFNγ Induced Gene Expression and STAT1 Phosphorylation
por: Rosowski, Emily E., et al.
Publicado: (2012)

Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses
por: Arranz-Solís, David, et al.
Publicado: (2023)

Protein kinase A negatively regulates Ca(2+) signalling in Toxoplasma gondii
por: Uboldi, Alessandro D., et al.
Publicado: (2018)

The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability
por: Paredes-Santos, Tatiana, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ji6oe46osf2iaa7nmirnfp8jns