Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics

With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and have generated analogues with improved potency. He...

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Detalles Bibliográficos
Autores principales: Dans, Madeline G., Piirainen, Henni, Nguyen, William, Khurana, Sachin, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Dawson, Aurelie T., Das, Sujaan, Parkyn Schneider, Molly, Jonsdottir, Thorey K., Gabriela, Mikha, Gancheva, Maria R., Tonkin, Christopher J., Mollard, Vanessa, Goodman, Christopher Dean, McFadden, Geoffrey I., Wilson, Danny W., Rogers, Kelly L., Barry, Alyssa E., Crabb, Brendan S., de Koning-Ward, Tania F., Sleebs, Brad E., Kursula, Inari, Gilson, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128974/
https://www.ncbi.nlm.nih.gov/pubmed/37053271
http://dx.doi.org/10.1371/journal.pbio.3002066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128974/
https://www.ncbi.nlm.nih.gov/pubmed/37053271
http://dx.doi.org/10.1371/journal.pbio.3002066

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