PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties

Obscurins are large filamentous proteins with crucial roles in the assembly, stability and regulation of muscle. Characteristic of these proteins is a tandem of two C-terminal kinase domains, PK1 and PK2, that are separated by a long intrinsically disordered sequence. The significance of this conser...

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Detalles Bibliográficos
Autores principales: Zacharchenko, Thomas, Dorendorf, Till, Locker, Nicolas, Van Dijk, Evert, Katzemich, Anja, Diederichs, Kay, Bullard, Belinda, Mayans, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129394/
https://www.ncbi.nlm.nih.gov/pubmed/37121260
http://dx.doi.org/10.1098/rsob.220350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129394/
https://www.ncbi.nlm.nih.gov/pubmed/37121260
http://dx.doi.org/10.1098/rsob.220350

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