45 Senolytic Therapy Transiently Reduces Inflammatory Markers in Primary Blood Mononuclear Cells of Individuals with Early Alzheimer’s Disease: Exploring the Conserved Transcriptional Response to Adversity as a Biomarker for Disease State

OBJECTIVES/GOALS: Determine if the Conserved Transcriptional Response to Adversity transcriptomic profile established in primary blood mononuclear cells (PBMC) of chronically stress caregivers, is present in individuals with early Alzheimer’s disease. Chronic stress is a risk factor for Alzheimer’s,...

Descripción completa

Detalles Bibliográficos
Autores principales: Garbarino, Valentina R., Xu, Peng, Zhang, Bin, Biggs, Glenn, Gonzales, Mitzi M., Orr, Miranda E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Biostatistics, Epidemiology, and Research Design
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129465/
http://dx.doi.org/10.1017/cts.2023.137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129465/
http://dx.doi.org/10.1017/cts.2023.137

Ejemplares similares