361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

OBJECTIVES/GOALS: Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). In this study, we perform an epigenetic-focused functional genomics screen in GBM organoids and identify WDR5 as an essential epigenetic regulator in the S...

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Detalles Bibliográficos
Autores principales: Hubert, Christopher, Mitchell, Kelly, Sprowls, Samuel, Shakya, Sajina, Arora, Sonali, Silver, Daniel J., Goins, Christopher M., Wallace, Lisa, Roversi, Gustavo, Schafer, Rachel, Kay, Kristen, Miller, Tyler E., Lauko, Adam, Bassett, John, Kashyap, Anjali, Kass, J. D’Amato, Mulkearns-Hubert, Erin E., Johnson, Sadie, Alvarado, Joseph, Rich, Jeremy N., Paddison, Patrick J., Patel, Anoop P., Stauffer, Shaun R., Hubert, Christopher G., Lathia, Justin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Precision Medicine/Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129484/
http://dx.doi.org/10.1017/cts.2023.401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129484/
http://dx.doi.org/10.1017/cts.2023.401

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