291 High Potency STING Agonists Induce Adaptive Immunity-Dependent Curative Responses in an Immune Checkpoint Blockade-Refractory Glioblastoma Model

OBJECTIVES/GOALS: Glioblastoma (GBM) is the most common and aggressive adult primary brain malignancy. Clinically, GBM is refractory to T cell immune checkpoint blockade (ICB), in part due to its dense immune suppressive myeloid stroma. Here we show that myeloid-targeting STING agonists can repolari...

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Detalles Bibliográficos
Autores principales: Lea, Spencer, Chen, Chao-Hsien, Wei, Jun, William, Ivana, Curran, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Precision Medicine/Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129570/
http://dx.doi.org/10.1017/cts.2023.347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129570/
http://dx.doi.org/10.1017/cts.2023.347

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