301 Inhibition of lysine-specific histone demethylase 1A (KDM1A/LSD1) attenuates DNA double strand break repair and enhances efficacy of temozolomide in glioblastoma

OBJECTIVES/GOALS: Glioblastoma (GBM) patients face a poor prognosis. Glioma stem cells (GSCs), a chemo resistant GBM subpopulation, possess enhanced DNA repair and elevated levels of epigenetic modifier KDM1A. This study aims to establish the significance of KDM1A in DNA repair and determine the pot...

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Detalles Bibliográficos
Autores principales: Alejo, Salvador, Palacios, Bridgitte, Venkata, Prabhakar Pitta, He, Yi, Li, Wenjing, Johnson, Jessica, Jayamohan, Sridharan, Vadlamudi, Ratna, Sareddy, Gangadhara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Precision Medicine/Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129675/
http://dx.doi.org/10.1017/cts.2023.355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129675/
http://dx.doi.org/10.1017/cts.2023.355

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