Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells

Resistance to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is a concerning problem. Polo-like kinase 1 (PLK1) is a key cell cycle modulator and is known to be associated with an activation of the PI3K pathway, which is related to the stabilization...

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Detalles Bibliográficos
Autores principales: Choi, Eun-Ji, Koo, Bon-Kwan, Hur, Eun-Hye, Moon, Ju Hyun, Kim, Ji Yun, Park, Han-Seung, Choi, Yunsuk, Lee, Kyoo-Hyung, Lee, Jung-Hee, Choi, Eun Kyung, Lee, Je-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129859/
https://www.ncbi.nlm.nih.gov/pubmed/36382510
http://dx.doi.org/10.4062/biomolther.2022.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129859/
https://www.ncbi.nlm.nih.gov/pubmed/36382510
http://dx.doi.org/10.4062/biomolther.2022.117

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