Combination therapy of doxorubicin and Sildenafil inhibits the growth of pediatric rhabdomyosarcoma

BACKGROUND: Overexpression of phosphodiesterase type 5 (PDE5) has been detected in many types of malignant tumors. Sildenafil, a potent and selective inhibitor of a cGMP-specific PDE5, has been found to enhance the cytotoxic activity of different chemotherapeutic agents including doxorubicin. The co...

Descripción completa

Detalles Bibliográficos
Autores principales: Urla, Cristian, Stagno, Matias Julian, Fuchs, Jörg, Warmann, Steven Walter, Schmid, Evi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129980/
https://www.ncbi.nlm.nih.gov/pubmed/35764701
http://dx.doi.org/10.1007/s00432-022-04092-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129980/
https://www.ncbi.nlm.nih.gov/pubmed/35764701
http://dx.doi.org/10.1007/s00432-022-04092-0

Ejemplares similares