Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility

Respiratory complex I is a major cellular energy transducer located in the inner mitochondrial membrane. Its inhibition by rotenone, a natural isoflavonoid, has been used for centuries by indigenous peoples to aid in fishing and, more recently, as a broad-spectrum pesticide or even a possible antica...

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Detalles Bibliográficos
Autores principales: Pereira, Caroline S., Teixeira, Murilo H., Russell, David A., Hirst, Judy, Arantes, Guilherme M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130173/
https://www.ncbi.nlm.nih.gov/pubmed/37185607
http://dx.doi.org/10.1038/s41598-023-33333-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130173/
https://www.ncbi.nlm.nih.gov/pubmed/37185607
http://dx.doi.org/10.1038/s41598-023-33333-6

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