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Single-molecule dynamics of DNA gyrase in evolutionarily distant bacteria Mycobacterium tuberculosis and Escherichia coli
DNA gyrase is an essential nucleoprotein motor present in all bacteria and is a major target for antibiotic treatment of Mycobacterium tuberculosis (MTB) infection. Gyrase hydrolyzes ATP to add negative supercoils to DNA using a strand passage mechanism that has been investigated using biophysical a...
Autores principales: | Galvin, Cooper J., Hobson, Matthew, Meng, Jonathan Xianglong, Ierokomos, Athena, Ivanov, Ivan E., Berger, James M., Bryant, Zev |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130225/ https://www.ncbi.nlm.nih.gov/pubmed/36775125 http://dx.doi.org/10.1016/j.jbc.2023.103003 |
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