Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma

INTRODUCTION: Glioblastoma is a malignant brain tumor with poor prognosis. Lactate is the main product of tumor cells, and its secretion may relate to immunocytes’ activation. However, its role in glioblastoma is poorly understood. METHODS: This work performed bulk RNA-seq analysis and single cell R...

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Detalles Bibliográficos
Autores principales: Wang, Zeyu, Dai, Ziyu, Zhang, Hao, Liang, Xisong, Zhang, Xun, Wen, Zhipeng, Luo, Peng, Zhang, Jian, Liu, Zaoqu, Zhang, Mingyu, Cheng, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130393/
https://www.ncbi.nlm.nih.gov/pubmed/37122693
http://dx.doi.org/10.3389/fimmu.2023.894853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130393/
https://www.ncbi.nlm.nih.gov/pubmed/37122693
http://dx.doi.org/10.3389/fimmu.2023.894853

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