DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity

The molecular and functional heterogeneity of pancreatic β-cells is well recognized, but the underlying mechanisms remain unclear. Pancreatic islets harbor a subset of β-cells that co-express tyrosine hydroxylase (TH), an enzyme involved in synthesis of catecholamines that repress insulin secretion....

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Detalles Bibliográficos
Autores principales: Parveen, Nazia, Wang, Jean Kimi, Bhattacharya, Supriyo, Cuala, Janielle, Rajkumar, Mohan Singh, Butler, Alexandra E., Wu, Xiwei, Shih, Hung-Ping, Georgia, Senta K., Dhawan, Sangeeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2023
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130487/
https://www.ncbi.nlm.nih.gov/pubmed/36607262
http://dx.doi.org/10.2337/db22-0506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130487/
https://www.ncbi.nlm.nih.gov/pubmed/36607262
http://dx.doi.org/10.2337/db22-0506

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