Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial. In studies on myocytes from CPVT mice, inhibition of proarrhythmic Ca(2+) waves was initi...

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Detalles Bibliográficos
Autores principales: Steer, Emma J., Yang, Zhaokang, Al-Owais, Moza M., Kirton, Hannah M., White, Edward, Steele, Derek S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130871/
https://www.ncbi.nlm.nih.gov/pubmed/37124209
http://dx.doi.org/10.3389/fphar.2023.1155601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130871/
https://www.ncbi.nlm.nih.gov/pubmed/37124209
http://dx.doi.org/10.3389/fphar.2023.1155601

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