Development of an IGF1R longevity variant mouse line using CRISPR/Cas9 genome editing

An insulin-like growth factor-1 receptor (IGF1R) variant in exon 6 (Arg-407-His) in Ashkenazi Jewish centenarians was previously found to be associated with reduced IGF1R activity. To further study this longevity associated IGF1R variant, we generated a novel mouse line carrying the R407H variant in...

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Detalles Bibliográficos
Autores principales: Dou, Yan, Darvas, Martin, Sharma, Kavita, Mathieu, Julie, Morton, John, Tan, Heidi, Soto-Palma, Carolina, Angelini, Luise A, McGowan, Sara J, Niedernhofer, Laura J, Suh, Yousin, Robbins, Paul D, Barzilai, Nir, Ladiges, Warren C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131096/
https://www.ncbi.nlm.nih.gov/pubmed/37113577
http://dx.doi.org/10.15761/jtbr.1000121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131096/
https://www.ncbi.nlm.nih.gov/pubmed/37113577
http://dx.doi.org/10.15761/jtbr.1000121

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