Cargando…

Development of an IGF1R longevity variant mouse line using CRISPR/Cas9 genome editing

An insulin-like growth factor-1 receptor (IGF1R) variant in exon 6 (Arg-407-His) in Ashkenazi Jewish centenarians was previously found to be associated with reduced IGF1R activity. To further study this longevity associated IGF1R variant, we generated a novel mouse line carrying the R407H variant in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dou, Yan, Darvas, Martin, Sharma, Kavita, Mathieu, Julie, Morton, John, Tan, Heidi, Soto-Palma, Carolina, Angelini, Luise A, McGowan, Sara J, Niedernhofer, Laura J, Suh, Yousin, Robbins, Paul D, Barzilai, Nir, Ladiges, Warren C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131096/ https://www.ncbi.nlm.nih.gov/pubmed/37113577 http://dx.doi.org/10.15761/jtbr.1000121

Ejemplares similares

Genetic signature of human longevity in PKC and NF‐κB signaling
por: Ryu, Seungjin, et al.
Publicado: (2021)

Modeling Alzheimer’s disease in progeria mice. An age-related concept
por: Sharma, Kavita, et al.
Publicado: (2018)

High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity
por: Gonzalez, Brenda, et al.
Publicado: (2022)

Targeting IGF1R signaling for brain aging and Alzheimer’s disease
por: Park, Joo Young, et al.
Publicado: (2022)

In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease
por: Lau, Cia-Hin, et al.
Publicado: (2017)

Regulation of IGF -1 signaling by microRNAs
por: Jung, Hwa Jin, et al.
Publicado: (2015)

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging
por: Zhang, Lei, et al.
Publicado: (2021)

Genetics, lifestyle and longevity: Lessons from centenarians
por: Govindaraju, Diddahally, et al.
Publicado: (2015)

Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians
por: Zhu, Yizhou, et al.
Publicado: (2023)

New horizons in life extension, healthspan extension and exceptional longevity
por: Couteur, David G Le, et al.
Publicado: (2022)

The influence of gender on inheritance of exceptional longevity
por: Deluty, Jennifer A., et al.
Publicado: (2015)

Association between Sleep Patterns and Health in Families with Exceptional Longevity
por: Klein, Lavy, et al.
Publicado: (2017)

Exceptional longevity is associated with decreased reproduction
por: Tabatabaie, Vafa, et al.
Publicado: (2011)

The role of dietary patterns and exceptional parental longevity in healthy aging
por: Gubbi, Sriram, et al.
Publicado: (2017)

CRISPR-based strategies for targeted transgene knock-in and gene correction
por: Lau, Cia-Hin, et al.
Publicado: (2020)

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms
por: Schumacher, Björn, et al.
Publicado: (2008)

OR25-01 Longitudinal Changes in the Hypothalamic-Pituitary-Testicular (HPT) Axis in Men with Longevity
por: He, Diana, et al.
Publicado: (2023)

Effect of Longevity Genetic Variants on the Molecular Aging Rate
por: Sebastiani, Paola, et al.
Publicado: (2020)

Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans
por: Atzmon, Gil, et al.
Publicado: (2006)

A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations
por: Kim, Seung-Soo, et al.
Publicado: (2021)

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms
por: Burd, Christin E., et al.
Publicado: (2016)

A geroscience mouse model for Alzheimer’s disease
por: Darvas, Martin, et al.
Publicado: (2019)

Mouse modeling for anxiety disorders in older adults
por: Darvas, Martin, et al.
Publicado: (2021)

Integrity of hypothalamic–pituitary‐testicular axis in exceptional longevity
por: Aleksic, Sandra, et al.
Publicado: (2022)

FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY
por: Zhang, Lei, et al.
Publicado: (2022)

FUCOIDANS ARE NOVEL SENOTHERAPEUTICS THAT ENHANCE SIRT6 AND DNA REPAIR ACTIVITY
por: Zhang, Lei, et al.
Publicado: (2022)

ETHNICITY-SPECIFIC EXTREME LONGEVITY VARIANTS IN A CONSORTIUM OF FOUR CENTENARIAN STUDIES
por: Bae, Harold, et al.
Publicado: (2022)

Human insulin/IGF-1 and familial longevity at middle age
por: Rozing, Maarten P., et al.
Publicado: (2009)

Targeting cellular senescence with novel senotherapeutics by design to extend healthspan
por: Zhang, Lei, et al.
Publicado: (2021)

CRISPR/Cas9‐mediated editing of 1‐aminocyclopropane‐1‐carboxylate oxidase1 enhances Petunia flower longevity
por: Xu, Junping, et al.
Publicado: (2019)

Modulation of Glucose Production by Central Insulin Requires IGF-1 Receptors in AgRP Neurons
por: Farias Quipildor, Gabriela, et al.
Publicado: (2021)

DNA damage—how and why we age?
por: Yousefzadeh, Matt, et al.
Publicado: (2021)

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
por: Milman, Sofiya, et al.
Publicado: (2014)

MEGA-ANALYSIS OF A CONSORTIUM OF FOUR CENTENARIAN STUDIES IDENTIFIES NOVEL EXTREME LONGEVITY VARIANTS
por: Bae, Harold, et al.
Publicado: (2022)

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism
por: Stout, Gerdine J, et al.
Publicado: (2013)

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
por: Zhao, Jing, et al.
Publicado: (2020)

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
por: Ewald, Collin Y., et al.
Publicado: (2014)

CRISPR-Mediated Epigenome Editing
por: Enríquez, Paul
Publicado: (2016)

Editing the microbiome the CRISPR way
por: Ramachandran, Gayetri, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1h26sss1bbveje1fugsnsvaev3