Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases

[Image: see text] Allylic cyclitols were investigated as covalent inhibitors of glycoside hydrolases by chemical, enzymatic, proteomic, and computational methods. This approach was inspired by the C(7) cyclitol natural product streptol glucoside, which features a potential carbohydrate leaving group...

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Detalles Bibliográficos
Autores principales: Grayfer, Tatyana D., Yamani, Khalil, Jung, Erik, Chesnokov, Gleb A., Ferrara, Isabella, Hsiao, Chien-Chi, Georgiou, Antri, Michel, Jeremy, Bailly, Aurélien, Sieber, Simon, Eberl, Leo, Gademann, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131216/
https://www.ncbi.nlm.nih.gov/pubmed/37124289
http://dx.doi.org/10.1021/jacsau.3c00037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131216/
https://www.ncbi.nlm.nih.gov/pubmed/37124289
http://dx.doi.org/10.1021/jacsau.3c00037

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