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Allylic Carbocyclic Inhibitors Covalently Bind Glycoside Hydrolases
[Image: see text] Allylic cyclitols were investigated as covalent inhibitors of glycoside hydrolases by chemical, enzymatic, proteomic, and computational methods. This approach was inspired by the C(7) cyclitol natural product streptol glucoside, which features a potential carbohydrate leaving group...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131216/ https://www.ncbi.nlm.nih.gov/pubmed/37124289 http://dx.doi.org/10.1021/jacsau.3c00037 |