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Evidence for Phosphorylation-Dependent, Dynamic, Regulation of mGlu5 and Homer2 in Expression of Cocaine Aversion in Mice
Cocaine-induced changes in the expression of the glutamate-related scaffolding protein Homer2 influence this drug’s psychostimulant and rewarding properties. In response to neuronal activity, Homer2 is phosphorylated on S117/S216 by calcium-calmodulin kinase IIα (CaMKIIα), which induces a rapid diss...
Autores principales: | Szumlinski, Karen K., Beltran, Jacqueline, van Doren, Eliyana, Jimenez Chavez, C. Leonardo, Domingo-Gonzalez, Racquel D., Reyes, Cindy M., Ary, Alexis W., Lang, Andrew, Guo, Weiruo, Worley, Paul F., Huber, Kimberly M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131536/ https://www.ncbi.nlm.nih.gov/pubmed/36973011 http://dx.doi.org/10.1523/ENEURO.0423-22.2023 |
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