Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera

BACKGROUND: Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein 43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron disease. Recent studies have shown that both C-terminal TDP-43 (C-TDP-43) aggregates and oligomers were neurotoxic and patholog...

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Detalles Bibliográficos
Autores principales: Tseng, Yu-Ling, Lu, Po-Chao, Lee, Chi-Chang, He, Ruei-Yu, Huang, Yung-An, Tseng, Yin-Chen, Cheng, Ting-Jen Rachel, Huang, Joseph Jen-Tse, Fang, Jim-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131537/
https://www.ncbi.nlm.nih.gov/pubmed/37101169
http://dx.doi.org/10.1186/s12929-023-00921-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131537/
https://www.ncbi.nlm.nih.gov/pubmed/37101169
http://dx.doi.org/10.1186/s12929-023-00921-7

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