Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint

Proteins involved in immune checkpoint pathways, such as CTLA4, PD1, and PD-L1, have become important targets for cancer immunotherapy; however, development of small molecule drugs targeting these pathways has proven difficult due to the nature of their protein–protein interfaces. Here, using a hier...

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Detalles Bibliográficos
Autores principales: Thakkar, Ravindra, Upreti, Deepa, Ishiguro, Susumu, Tamura, Masaaki, Comer, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131585/
https://www.ncbi.nlm.nih.gov/pubmed/37122540
http://dx.doi.org/10.1039/d2md00409g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131585/
https://www.ncbi.nlm.nih.gov/pubmed/37122540
http://dx.doi.org/10.1039/d2md00409g

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