Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry

The screening of covalent or ‘reactive’ fragment libraries against proteins is becoming an integral approach in hit identification, enabling the development of targeted covalent inhibitors and tools. To date, reactive fragment screening has been limited to targeting cysteine residues, thus restricti...

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Detalles Bibliográficos
Autores principales: Thomas, Ross P., Grant, Emma K., Dickinson, Eleanor R., Zappacosta, Francesca, Edwards, Lee J., Hann, Michael M., House, David, Tomkinson, Nicholas C. O., Bush, Jacob T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131605/
https://www.ncbi.nlm.nih.gov/pubmed/37122547
http://dx.doi.org/10.1039/d2md00453d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131605/
https://www.ncbi.nlm.nih.gov/pubmed/37122547
http://dx.doi.org/10.1039/d2md00453d

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