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Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry
The screening of covalent or ‘reactive’ fragment libraries against proteins is becoming an integral approach in hit identification, enabling the development of targeted covalent inhibitors and tools. To date, reactive fragment screening has been limited to targeting cysteine residues, thus restricti...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
RSC
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131605/ https://www.ncbi.nlm.nih.gov/pubmed/37122547 http://dx.doi.org/10.1039/d2md00453d |