Phosphomevalonate Kinase Controls β‐Catenin Signaling via the Metabolite 5‐Diphosphomevalonate

β‐catenin signaling is abnormally activated in cancer. Here, this work screens the mevalonate metabolic pathway enzyme PMVK to stabilize β‐catenin signaling using a human genome‐wide library. On the one hand, PMVK‐produced MVA‐5PP competitively binds to CKIα to prevent β‐catenin Ser45 phosphorylatio...

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Detalles Bibliográficos
Autores principales: Chen, Zhiqiang, Zhou, Xinyi, Zhou, Xiaojun, Tang, Yi, Lu, Mingzhu, Zhao, Jianhong, Tian, Chenhui, Wu, Mingzhi, Liu, Yanliang, Prochownik, Edward V., Wang, Fubing, Li, Youjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131864/
https://www.ncbi.nlm.nih.gov/pubmed/36808719
http://dx.doi.org/10.1002/advs.202204909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131864/
https://www.ncbi.nlm.nih.gov/pubmed/36808719
http://dx.doi.org/10.1002/advs.202204909

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