Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine

In this study, engineered imine reductases (IREDs) of IRED M5, originally from Actinoalloteichus hymeniacidonis, were obtained through structure-guided semi-rational design. By focusing on mutagenesis of the residues that directly interact with the ketone donor moiety, we identified two residues W23...

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Detalles Bibliográficos
Autores principales: Zhang, Jun, Ma, Yaqing, Zhu, Fangfang, Bao, Jinping, Wu, Qiaqing, Gao, Shu-Shan, Cui, Chengsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132124/
https://www.ncbi.nlm.nih.gov/pubmed/37123194
http://dx.doi.org/10.1039/d2sc07014f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132124/
https://www.ncbi.nlm.nih.gov/pubmed/37123194
http://dx.doi.org/10.1039/d2sc07014f

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