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Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine
In this study, engineered imine reductases (IREDs) of IRED M5, originally from Actinoalloteichus hymeniacidonis, were obtained through structure-guided semi-rational design. By focusing on mutagenesis of the residues that directly interact with the ketone donor moiety, we identified two residues W23...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132124/ https://www.ncbi.nlm.nih.gov/pubmed/37123194 http://dx.doi.org/10.1039/d2sc07014f |