Cargando…

Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition

Diabetes is associated with increased risk for kidney disease, heart failure, and mortality. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent these adverse outcomes; however, the mechanisms involved are not clear. We generated a roadmap of the metabolic alterations that occur in different...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kogot-Levin, Aviram, Riahi, Yael, Abramovich, Ifat, Mosenzon, Ofri, Agranovich, Bella, Kadosh, Liat, Ben-Haroush Schyr, Rachel, Kleiman, Doron, Hinden, Liad, Cerasi, Erol, Ben-Zvi, Danny, Bernal-Mizrachi, Ernesto, Tam, Joseph, Gottlieb, Eyal, Leibowitz, Gil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132155/ https://www.ncbi.nlm.nih.gov/pubmed/36809274 http://dx.doi.org/10.1172/jci.insight.164296

Ejemplares similares

Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors
por: Kogot-Levin, Aviram, et al.
Publicado: (2020)

Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism
por: Haran, Arnon, et al.
Publicado: (2023)

Kidney Proximal Tubule GLUT2—More than Meets the Eye
por: Ahmad, Majdoleen, et al.
Publicado: (2022)

RF36 | PSUN93 A Role for Somatostatin in Regulating Weight Regain after Bariatric Surgery in Mice
por: Arad, Yhara, et al.
Publicado: (2022)

Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function
por: Hinden, Liad, et al.
Publicado: (2022)

Maternal antagonism of Glp1 reverses the adverse outcomes of sleeve gastrectomy on mouse offspring
por: Hefetz, Liron, et al.
Publicado: (2022)

Paving the way to precision medicine for diabetic kidney disease: the PRIORITY trial
por: Schechter, Meir, et al.
Publicado: (2020)

Preventing all‐cause hospitalizations in type 2 diabetes with sodium‐glucose cotransporter‐2 inhibitors and glucagon‐like peptide‐1 receptor agonists: A narrative review and proposed clinical approach
por: Schechter, Meir, et al.
Publicado: (2022)

Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
por: Amleh, Athar, et al.
Publicado: (2023)

Metabolic adaptation to consume butyrate under prolonged resource exhaustion
por: Katz, Sophia, et al.
Publicado: (2023)

β‐Cell failure in type 2 diabetes
por: Leibowitz, Gil, et al.
Publicado: (2011)

Sleeve Gastrectomy Is Associated with a Greater Reduction in Plasma Liver Enzymes Than Bypass Surgeries—A Registry-Based Two-Year Follow-Up Analysis
por: Azulai, Shira, et al.
Publicado: (2021)

Bariatric Surgery Affects Plasma Levels of Alanine Aminotransferase Independent of Weight Loss: A Registry-Based Study
por: Azulai, Shira, et al.
Publicado: (2021)

Efficacy of liraglutide added to sodium‐glucose cotransporter‐2 inhibitors in type 2 diabetes, stratified by baseline characteristics: Post‐hoc analysis of LIRA‐ADD2SGLT2i
por: Blonde, Lawrence, et al.
Publicado: (2021)

Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse
por: Riahi, Yael, et al.
Publicado: (2018)

Cardiorenal outcomes with sodium/glucose cotransporter-2 inhibitors in patients with type 2 diabetes and low kidney risk: real world evidence
por: Schechter, Meir, et al.
Publicado: (2021)

Upregulation of Mitochondrial Content in Cytochrome c Oxidase Deficient Fibroblasts
por: Kogot-Levin, Aviram, et al.
Publicado: (2016)

Correction: AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells
por: Shaked, Maayan, et al.
Publicado: (2012)

AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells
por: Shaked, Maayan, et al.
Publicado: (2011)

The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet- and Genetic-Induced Obesity
por: Ben-Cnaan, Elad, et al.
Publicado: (2022)

Intensification of Insulin Therapy for Type 2 Diabetic Patients in Primary Care: Basal-Bolus Regimen Versus Premix Insulin Analogs: When and for whom?
por: Mosenzon, Ofri, et al.
Publicado: (2013)

Early Insulinization to Prevent Diabetes Progression
por: Raz, Itamar, et al.
Publicado: (2013)

Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients
por: Willi, Lubna, et al.
Publicado: (2022)

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1
por: Bachar, Etti, et al.
Publicado: (2009)

Lymphocyte counts may predict a good response to mesenchymal stromal cells therapy in graft versus host disease patients
por: Hinden, Liad, et al.
Publicado: (2019)

The Expression of the Beta Cell-Derived Autoimmune Ligand for the Killer Receptor Nkp46 Is Attenuated in Type 2 Diabetes
por: Gur, Chamutal, et al.
Publicado: (2013)

Sleeve Gastrectomy Suppresses Hepatic Glucose Production and Increases Hepatic Insulin Clearance Independent of Weight Loss
por: Ben-Haroush Schyr, Rachel, et al.
Publicado: (2021)

Comprehensive Analysis of (13)C(6) Glucose Fate in the Hypoxia-Tolerant Blind Mole Rat Skin Fibroblasts
por: Miskevich, Dmitry, et al.
Publicado: (2021)

Glutamine Homeostasis and Its Role in the Adaptive Strategies of the Blind Mole Rat, Spalax
por: Miskevich, Dmitry, et al.
Publicado: (2021)

Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells
por: Tzukerman, Maty, et al.
Publicado: (2022)

A Novel Indoline Derivative Ameliorates Diabesity-Induced Chronic Kidney Disease by Reducing Metabolic Abnormalities
por: Permyakova, Anna, et al.
Publicado: (2020)

Systemic Changes in Endocannabinoids and Endocannabinoid-like Molecules in Response to Partial Nephrectomy-Induced Ischemia in Humans
por: Rothner, Ariel, et al.
Publicado: (2023)

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress–Induced Diabetes
por: Bachar-Wikstrom, Etty, et al.
Publicado: (2013)

Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice
por: Samuel, Itia, et al.
Publicado: (2022)

Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest
por: Saragovi, Amijai, et al.
Publicado: (2020)

Physiological impact of in vivo stable isotope tracing on cancer metabolism
por: Grima-Reyes, Manuel, et al.
Publicado: (2021)

Diabetes and Stroke: What Are the Connections?
por: Mosenzon, Ofri, et al.
Publicado: (2023)

Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis
por: Baraghithy, Saja, et al.
Publicado: (2021)

Peripheral Cannabinoid-1 Receptor Blockade Ameliorates Cystitis Severity
por: Hinden, Liad, et al.
Publicado: (2023)

Hepatic targeting of the centrally active cannabinoid 1 receptor (CB(1)R) blocker rimonabant via PLGA nanoparticles for treating fatty liver disease and diabetes
por: Hirsch, Shira, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ci6mnlom3ng309l79esu8raim6