Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response

Prodrugs reliant on microbial activation are widely used but exhibit a range of efficacies that remain poorly understood. The anti-inflammatory compound 5-aminosalicylic acid (5-ASA), which is packaged in a variety of azo-linked prodrugs provided to most Ulcerative Colitis (UC) patients, shows confo...

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Detalles Bibliográficos
Autores principales: Simpson, Joshua B., Sekela, Josh J., Carry, Benjamin S., Beaty, Violet, Patel, Shakshi, Redinbo, Matthew. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132220/
https://www.ncbi.nlm.nih.gov/pubmed/37122075
http://dx.doi.org/10.1080/19490976.2023.2203963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132220/
https://www.ncbi.nlm.nih.gov/pubmed/37122075
http://dx.doi.org/10.1080/19490976.2023.2203963

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