Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanoma

In this study, a novel series of histone deacetylases 6 (HDAC6) inhibitors containing polycyclic aromatic rings were discovered and evaluated for their pharmacological activities. The most potent compound 10c exhibited high HDAC6 inhibitory activity (IC(50) = 261 nM) and excellent HDAC6 selectivity...

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Detalles Bibliográficos
Autores principales: Peng, Xiaopeng, Yu, Ziwen, Surineni, Goverdhan, Deng, Bulian, Zhang, Meizhu, Li, Chuan, Sun, Zhiqiang, Pan, Wanyi, Liu, Yao, Liu, Shenglan, Yu, Bin, Chen, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132229/
https://www.ncbi.nlm.nih.gov/pubmed/37096557
http://dx.doi.org/10.1080/14756366.2023.2201408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132229/
https://www.ncbi.nlm.nih.gov/pubmed/37096557
http://dx.doi.org/10.1080/14756366.2023.2201408

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