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HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients show lower humoral vaccine responsiveness than immunocompetent individuals. HLA diversity, measured by the HLA evolutionary divergence (HED) metrics, reflects the diversity of the antigenic repertoire presented to T cells, and...

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Detalles Bibliográficos
Autores principales: Villemonteix, Juliette, Allain, Vincent, Verstraete, Emma, Jorge-Cordeiro, Debora, Socié, Gérard, Xhaard, Alienor, Feray, Cyrille, Caillat-Zucman, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132830/
https://www.ncbi.nlm.nih.gov/pubmed/37168557
http://dx.doi.org/10.1016/j.isci.2023.106763