Cargando…

Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy

Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered. Fuzi, the lateral roots of Aconitum carmichaelii, shows unique e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Ji-Chao, Jin, Cai-Cai, Wei, Xiao-Li, Xu, Rui-Bing, Wang, Ruo-Yu, Zhang, Zhi-Meng, Tang, Bo, Yu, Jin-Mei, Yu, Jiao-Jiao, Shang, Shuang, Lv, Xiao-Xi, Hua, Fang, Li, Ping-Ping, Hu, Zhuo-Wei, Shen, Yong-Mei, Wang, Feng-Peng, Ma, Xiu-Ying, Cui, Bing, Geng, Fu-Neng, Zhang, Xiao-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132857/ https://www.ncbi.nlm.nih.gov/pubmed/37124193 http://dx.doi.org/10.3389/fphar.2023.1118017

Ejemplares similares

On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
por: Wang, Feng-Peng, et al.
Publicado: (2020)

The true colors of autophagy in doxorubicin-induced cardiotoxicity
por: Xiao, Bin, et al.
Publicado: (2019)

14-Benzoylmesaconine hydrochloride methanol monosolvate
por: Mu, Yan, et al.
Publicado: (2011)

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity
por: Koleini, Navid, et al.
Publicado: (2017)

Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity
por: Zhang, Xin, et al.
Publicado: (2019)

Metformin-induced AMPK activation promotes cisplatin resistance through PINK1/Parkin dependent mitophagy in gastric cancer
por: Xiao, Yi-Yi, et al.
Publicado: (2022)

Breviscapine remodels myocardial glucose and lipid metabolism by regulating serotonin to alleviate doxorubicin-induced cardiotoxicity
por: Li, Meng-Jiao, et al.
Publicado: (2022)

Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy
por: Li, Weili, et al.
Publicado: (2022)

Role of Pink1-mediated mitophagy in adenomyosis
por: Chen, Minmin, et al.
Publicado: (2023)

Effect of fermented Cordyceps sinensis on doxorubicin-induced cardiotoxicity in rats
por: Wu, Rong, et al.
Publicado: (2018)

RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway
por: Jiao, Yuheng, et al.
Publicado: (2022)

Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-γ in Mice
por: Yan, Jie, et al.
Publicado: (2019)

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27
por: Bernard, Yohann, et al.
Publicado: (2011)

Attenuation of Doxorubicin-Induced Cardiotoxicity by mdivi-1: A Mitochondrial Division/Mitophagy Inhibitor
por: Gharanei, Mayel, et al.
Publicado: (2013)

Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation
por: Zhang, Lei, et al.
Publicado: (2022)

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT
por: Zhang, Xin, et al.
Publicado: (2019)

Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria
por: Xie, Xiao-Qing, et al.
Publicado: (2023)

Pan-Cancer Analysis of the Mitophagy-Related Protein PINK1 as a Biomarker for the Immunological and Prognostic Role
por: Zhu, Lizhe, et al.
Publicado: (2020)

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin
por: Hou, Kai, et al.
Publicado: (2021)

PHB2 Alleviates Neurotoxicity of Prion Peptide PrP(106–126) via PINK1/Parkin-Dependent Mitophagy
por: Zheng, Xiaohui, et al.
Publicado: (2023)

Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy
por: Xiang, Ruo‐Lan, et al.
Publicado: (2019)

Oleoylethanolamide as a New Therapeutic Strategy to Alleviate Doxorubicin-Induced Cardiotoxicity
por: Qin, Yeyu, et al.
Publicado: (2022)

SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy
por: Wang, Yiyang, et al.
Publicado: (2020)

Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis
por: Li, Weili, et al.
Publicado: (2022)

Doxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation
por: Tian, Chao, et al.
Publicado: (2022)

Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway
por: Wang, Jiawei, et al.
Publicado: (2020)

Involvement of Abnormal Gut Microbiota Composition and Function in Doxorubicin-Induced Cardiotoxicity
por: Huang, Jie, et al.
Publicado: (2022)

GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity
por: Xiao, Zilong, et al.
Publicado: (2023)

Inhibition of mitoNEET induces Pink1-Parkin-mediated mitophagy
por: Lee, Seunghee, et al.
Publicado: (2022)

Morphine induces dysfunction of PINK1/Parkin-mediated mitophagy in spinal cord neurons implying involvement in antinociceptive tolerance
por: Kong, Hong, et al.
Publicado: (2019)

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2017)

MitoQ inhibits hepatic stellate cell activation and liver fibrosis by enhancing PINK1/parkin-mediated mitophagy
por: Dou, Shi-Ying, et al.
Publicado: (2021)

Trophoblast Stem-Cell-Derived Exosomes Alleviate Cardiotoxicity of Doxorubicin via Improving Mfn2-Mediated Mitochondrial Fusion
por: Duan, Junfeng, et al.
Publicado: (2023)

Neuraminidase1 Inhibitor Protects Against Doxorubicin-Induced Cardiotoxicity via Suppressing Drp1-Dependent Mitophagy
por: Qin, Yating, et al.
Publicado: (2021)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Role of acetylation in doxorubicin-induced cardiotoxicity
por: Li, Daisong, et al.
Publicado: (2021)

HIF-1α Alleviates High-Glucose-Induced Renal Tubular Cell Injury by Promoting Parkin/PINK1-Mediated Mitophagy
por: Yu, Lu, et al.
Publicado: (2022)

Melatonin attenuates doxorubicin‐induced cardiotoxicity through preservation of YAP expression
por: Li, Hai‐ru, et al.
Publicado: (2020)

The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury
por: Wang, Ying, et al.
Publicado: (2020)

TLR9 deficiency alleviates doxorubicin‐induced cardiotoxicity via the regulation of autophagy
por: Guo, Zhen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0l48b0agrtif2ps0hthigvn7e1