CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion

In eukaryotes, genomic DNA is extruded into loops by cohesin(1). By restraining this process, the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating domains (TADs)(2,3) that have important roles in gene regulation and recombination during development and disease(1,4–...

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Detalles Bibliográficos
Autores principales: Davidson, Iain F., Barth, Roman, Zaczek, Maciej, van der Torre, Jaco, Tang, Wen, Nagasaka, Kota, Janissen, Richard, Kerssemakers, Jacob, Wutz, Gordana, Dekker, Cees, Peters, Jan-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132984/
https://www.ncbi.nlm.nih.gov/pubmed/37076620
http://dx.doi.org/10.1038/s41586-023-05961-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132984/
https://www.ncbi.nlm.nih.gov/pubmed/37076620
http://dx.doi.org/10.1038/s41586-023-05961-5

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