The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading to rapid inactivation of the enzyme. Here we show that human and mouse cells expressing a GAPDH mutant lacking this redox switch retain...

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Detalles Bibliográficos
Autores principales: Talwar, Deepti, Miller, Colin G., Grossmann, Justus, Szyrwiel, Lukasz, Schwecke, Torsten, Demichev, Vadim, Mikecin Drazic, Ana-Matea, Mayakonda, Anand, Lutsik, Pavlo, Veith, Carmen, Milsom, Michael D., Müller-Decker, Karin, Mülleder, Michael, Ralser, Markus, Dick, Tobias P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132988/
https://www.ncbi.nlm.nih.gov/pubmed/37024754
http://dx.doi.org/10.1038/s42255-023-00781-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10132988/
https://www.ncbi.nlm.nih.gov/pubmed/37024754
http://dx.doi.org/10.1038/s42255-023-00781-3

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