An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1

BACKGROUND: Lung cancer cells overexpress mucin 1 (MUC1) and active subunit MUC1-CT. Although a peptide blocks MUC1 signalling, metabolites targeting MUC1 are not well studied. AICAR is a purine biosynthesis intermediate. METHODS: Cell viability and apoptosis were measured in AICAR-treated EGFR-muta...

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Detalles Bibliográficos
Autores principales: Aftab, Fareesa, Rodriguez-Fuguet, Alice, Silva, Luis, Kobayashi, Ikei S., Sun, Jiao, Politi, Katerina, Levantini, Elena, Zhang, Wei, Kobayashi, Susumu S., Zhang, Wen Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133251/
https://www.ncbi.nlm.nih.gov/pubmed/36810913
http://dx.doi.org/10.1038/s41416-023-02196-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133251/
https://www.ncbi.nlm.nih.gov/pubmed/36810913
http://dx.doi.org/10.1038/s41416-023-02196-z

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