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High spontaneous integration rates of end-modified linear DNAs upon mammalian cell transfection
In gene therapy, potential integration of therapeutic transgene into host cell genomes is a serious risk that can lead to insertional mutagenesis and tumorigenesis. Viral vectors are often used as the gene delivery vehicle, but they are prone to undergoing integration events. More recently, non-vira...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133325/ https://www.ncbi.nlm.nih.gov/pubmed/37100816 http://dx.doi.org/10.1038/s41598-023-33862-0 |