Cargando…

Dynamics of a model for the degradation mechanism of aggregated α-synuclein in Parkinson's disease

Accumulation of the misfolded synaptic protein α-synuclein (αSyn(*)) is a hallmark of neurodegenerative disease in Parkinson's disease (PD). Recent studies suggest that the autophagy lysosome pathway (ALP) including both the Beclin1-associated and mTOR-signaling pathways is involved in the αSyn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Bojie, Yang, Zhuoqin, Hao, Lijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133481/ https://www.ncbi.nlm.nih.gov/pubmed/37122994 http://dx.doi.org/10.3389/fncom.2023.1068150

Ejemplares similares

Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology
por: Yuan, Xin, et al.
Publicado: (2022)

Models of α-synuclein aggregation in Parkinson’s disease
por: Giráldez-Pérez, Rosa María, et al.
Publicado: (2014)

Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
por: Liu, Zhiyong, et al.
Publicado: (2023)

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
por: Bridi, Jessika C., et al.
Publicado: (2018)

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients
por: Piancone, Federica, et al.
Publicado: (2021)

Underlying Mechanisms of Cooperativity, Input Specificity, and Associativity of Long-Term Potentiation Through a Positive Feedback of Local Protein Synthesis
por: Hao, Lijie, et al.
Publicado: (2018)

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
por: Tatenhorst, Lars, et al.
Publicado: (2016)

α-synuclein pathogenesis in hiPSC models of Parkinson’s disease
por: Baena-Montes, Jara M., et al.
Publicado: (2021)

Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation
por: Zheng, Yuan, et al.
Publicado: (2018)

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease
por: Du, Tingting, et al.
Publicado: (2021)

The Roles of ATP13A2 Gene Mutations Leading to Abnormal Aggregation of α-Synuclein in Parkinson’s Disease
por: Zhang, Fan, et al.
Publicado: (2022)

Dynamical Mechanisms for Gene Regulation Mediated by Two Noncoding RNAs in Long-Term Memory Formation
por: Hao, Lijie, et al.
Publicado: (2021)

Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity
por: Abul Khair, Salema B., et al.
Publicado: (2018)

Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease
por: Canerina-Amaro, Ana, et al.
Publicado: (2019)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
por: Lee, Jihoon, et al.
Publicado: (2023)

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
por: Smith, Jessica K., et al.
Publicado: (2023)

Erythrocytic α-Synuclein Species for Parkinson’s Disease Diagnosis and the Correlations With Clinical Characteristics
por: Yu, Zhenwei, et al.
Publicado: (2022)

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
por: Javed, Hayate, et al.
Publicado: (2019)

Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
por: Hou, Kaiying, et al.
Publicado: (2023)

Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
por: Ohgita, Takashi, et al.
Publicado: (2022)

Human pericytes degrade diverse α-synuclein aggregates
por: Dieriks, Birger Victor, et al.
Publicado: (2022)

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy
por: Dai, Lijun, et al.
Publicado: (2021)

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
por: Ikenaka, Kensuke, et al.
Publicado: (2019)

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis
por: Butkovich, Laura M., et al.
Publicado: (2018)

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
por: Zhang, Jiaming, et al.
Publicado: (2019)

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
por: O’Hara, Darren M., et al.
Publicado: (2020)

Voltage-Gated Calcium Channels and α-Synuclein: Implications in Parkinson’s Disease
por: Leandrou, Emmanouela, et al.
Publicado: (2019)

Correction: Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
por: Lee, Jihoon, et al.
Publicado: (2023)

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
por: Emin, Derya, et al.
Publicado: (2022)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

New Roles of Glycosaminoglycans in α-Synuclein Aggregation in a Cellular Model of Parkinson Disease
por: Lehri-Boufala, Sonia, et al.
Publicado: (2015)

Zonisamide Attenuates α-Synuclein Neurotoxicity by an Aggregation-Independent Mechanism in a Rat Model of Familial Parkinson’s Disease
por: Arawaka, Shigeki, et al.
Publicado: (2014)

Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation
por: Chlebowicz, Julita, et al.
Publicado: (2023)

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
por: Vieira, Bruno Di Marco, et al.
Publicado: (2015)

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation
por: Popova, Blagovesta, et al.
Publicado: (2021)

Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
por: Han, Deqiang, et al.
Publicado: (2020)

Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage
por: Majbour, Nour, et al.
Publicado: (2022)

Commentary: Discriminating α-synuclein strains in parkinson's disease and multiple system atrophy
por: Fellner, Lisa, et al.
Publicado: (2020)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_td1f46hcef4itertcbpg9ncald