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Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells

The sinoatrial node (SAN) and subsidiary pacemakers in the cardiac conduction system generate spontaneous electrical activity which is indispensable for electrical and therefore contractile function of the heart. The hyperpolarisation-activated cyclic nucleotide-gated channel HCN4 is responsible for...

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Detalles Bibliográficos
Autores principales: Congreve, Samitha Dilini, Main, Alice, Butler, Andrew S., Gao, Xing, Brown, Elaine, Du, Chunyun, Choisy, Stephanié C., Cheng, Hongwei, Hancox, Jules C., Fuller, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133559/
https://www.ncbi.nlm.nih.gov/pubmed/37123274
http://dx.doi.org/10.3389/fphys.2023.1163339