Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors

αD-conotoxins are 11 kDa homodimers that potently inhibit nicotinic acetylcholine receptors (nAChRs) through a non-competitive (allosteric) mechanism. In this study, we describe the allosteric binding mode of the granulin-like C-terminal (CTD) of VxXXB bound to Lymnea stagnalis acetylcholine binding...

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Detalles Bibliográficos
Autores principales: Ho, Thao NT, Abraham, Nikita, Lewis, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133702/
https://www.ncbi.nlm.nih.gov/pubmed/37124228
http://dx.doi.org/10.3389/fphar.2023.1170514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133702/
https://www.ncbi.nlm.nih.gov/pubmed/37124228
http://dx.doi.org/10.3389/fphar.2023.1170514

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