A model-based optimization strategy to achieve fast and robust freeze-drying cycles

Freeze-drying is a time and cost-intensive process. The primary drying phase is the main target in a process optimization exercise. Biopharmaceuticals require an amorphous matrix for stabilization, which may collapse during primary drying if the critical temperature of the formulation is exceeded. T...

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Detalles Bibliográficos
Autores principales: Vanbillemont, Brecht, Greiner, Anna-Lena, Ehrl, Vanessa, Menzen, Tim, Friess, Wolfgang, Hawe, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133743/
https://www.ncbi.nlm.nih.gov/pubmed/37125084
http://dx.doi.org/10.1016/j.ijpx.2023.100180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133743/
https://www.ncbi.nlm.nih.gov/pubmed/37125084
http://dx.doi.org/10.1016/j.ijpx.2023.100180

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